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Updated: Apr 8, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Connexins and pannexins in the immune system and lymphatic organs
Aaron M Glass1, Elizabeth G Snyder, Steven M Taffet
1Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY, 13210, USA.
Abstract:
Connexin43 and pannexin1 are found in immune cells. While gap junctional communication has been demonstrated between immune cells, hemichannels have been implicated in many cellular functions. Among the functions involved as being connexin dependent and pannexin dependent are cell migration, phagocytosis, antigen presentation, T-cell reactivity and B-cell responses. Surprisingly, many of these connexin-related and pannexin-related functions are not recapitulated in in vivo models. This is leading to a reevaluation of the role of these proteins in immune function.
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