Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Randomized Experiments

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...

Flail Chest-II

Flail Chest-II

Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

2026 Clinical Practice Guideline Update by the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society on The Management of Community-Acquired Pneumonia in Infants and Children Older than 3 Months of Age: The Use of Pleural fluid drainage compared to Surgical Debridement.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Same author

ACR Appropriateness Criteria® Chest Pain-Child.

Journal of the American College of Radiology : JACR·2026

Same author

Surgical outcomes in neonates and infants with congenital choledochal malformation: analysis of the Pediatric Health Information System (PHIS) database.

Pediatric surgery international·2026

Same author

Outcomes of laparoscopic orchiopexy for intra-abdominal testis: A single institutional experience.

Journal of pediatric surgery·2025

Same author

A multi-institutional comparison of management techniques for infants with giant omphalocele.

Journal of pediatric surgery·2025

Same author

Use of Ovarian Tumor Markers in Prediction of Malignancy Risk in Pediatric and Adolescent Patients.

The Journal of surgical research·2025

Search research articles

Related Experiment Video

Updated: Apr 8, 2026

Prone Lateral Minimally Invasive Retropleural Corpectomy Using a Rotatable Radiolucent Jackson Table

Prone Lateral Minimally Invasive Retropleural Corpectomy Using a Rotatable Radiolucent Jackson Table

Published on: July 3, 2025

Pectus excavatum: Benefit of randomization.

Brian G A Dalton¹, Katherine W Gonzalez¹, Daniel L Millspaugh²

¹Department of Pediatric Surgery, Children's Mercy Hospital, Kansas City, MO.

Journal of Pediatric Surgery

|June 24, 2015

Summary

Participating in clinical trials for pectus excavatum repair involving epidural analgesia versus patient-controlled analgesia (PCA) offers benefits, including shorter hospital stays and reduced epidural failure rates, regardless of the pain management method used.

Keywords:

Benefit Epidural Length of Stay Patient controlled analgesia Pectus Excavatum Randomization

More Related Videos

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

Related Experiment Videos

Last Updated: Apr 8, 2026

Prone Lateral Minimally Invasive Retropleural Corpectomy Using a Rotatable Radiolucent Jackson Table

Prone Lateral Minimally Invasive Retropleural Corpectomy Using a Rotatable Radiolucent Jackson Table

Published on: July 3, 2025

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

Area of Science:

Thoracic surgery
Pain management
Clinical trial methodology

Background:

Minimally invasive pectus repair causes significant post-operative pain, influencing recovery.
Previous randomized trials compared epidural catheters to patient-controlled analgesia (PCA) for pain management.

Purpose of the Study:

To compare outcomes of patients enrolled in randomized trials versus those not enrolled in trials for pectus excavatum repair.

Main Methods:

Retrospective chart review of non-trial patients (October 2006 - June 2014).
Comparison of perioperative outcomes between enrolled (IS) and non-enrolled (OS) patients.

Main Results:

Enrolled patients (IS, n=135) had shorter length of stay and faster return to regular diet than non-enrolled (OS, n=195).
No significant differences in pain scores, operative time, or complication rates.
Significantly lower epidural failure rates in the IS group, reducing the need for PCA substitution.

Conclusions:

Enrollment in randomized trials comparing epidural to PCA for pectus excavatum repair yields benefits.
These benefits are observed irrespective of the specific pain management arm utilized in the trial.