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Somatosensation01:33

Somatosensation

45.8K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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Tactile and Chemical Senses01:27

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Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Responses to Gravity and Touch02:26

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Related Experiment Video

Updated: Apr 8, 2026

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus
07:49

Measuring Changes in Tactile Sensitivity in the Hind Paw of Mice Using an Electronic von Frey Apparatus

Published on: December 19, 2013

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Mammalian touch catches up.

Carolyn M Walsh1, Diana M Bautista1, Ellen A Lumpkin2

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.

Current Opinion in Neurobiology
|June 24, 2015
PubMed
Summary
This summary is machine-generated.

Mammalian touch relies on specialized skin receptors. Recent advances in molecular markers and the discovery of Piezo genes are rapidly improving our understanding of touch reception mechanisms.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Dermatology

Background:

  • Mammalian touch perception involves diverse skin receptors.
  • Understanding the molecular and cellular basis of mammalian touch has lagged behind other sensory systems.
  • Recent breakthroughs are accelerating progress in this field.

Purpose of the Study:

  • To summarize recent advancements in understanding mammalian touch reception.
  • To highlight the role of molecular markers and Piezo genes.
  • To elucidate the cellular and molecular mechanisms underlying touch sensation.

Main Methods:

  • Utilized cell-type-specific molecular markers to identify and characterize touch sensory neurons.
  • Investigated the functional and anatomical properties of these neurons.
  • Leveraged the discovery of Piezo genes to explore mechanotransduction pathways.

Main Results:

  • Cell-type-specific markers enabled matching neuronal properties to touch features, revealing a cellular code for touch.
  • Non-neuronal cells, including Merkel cells and keratinocytes, were identified as crucial for touch reception.
  • Piezo genes were identified as key molecular players in mechanotransduction.

Conclusions:

  • Recent molecular and genetic discoveries have significantly advanced the understanding of mammalian touch.
  • A cellular code for touch is emerging, involving both neuronal and non-neuronal cell types.
  • Mechanically activated channels, particularly Piezo genes, are central to touch mechanotransduction.