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Androgen receptor aberrations in the era of abiraterone and enzalutamide

Florian Jentzmik1, Anca Azoitei1, Friedemann Zengerling1

  • 1Department of Urology, Ulm University Medical Center, Prittwitzstrasse 43, 89075, Ulm, Germany.

World Journal of Urology
|June 24, 2015
PubMed

Insights

Prostate cancer often becomes castration-resistant despite androgen deprivation therapy. This review details androgen receptor signaling mechanisms driving this resistance and impacting treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Urology

Background:

  • Prostate cancer is a leading cause of cancer death in men.
  • Androgen deprivation therapy is the primary treatment for advanced prostate cancer.
  • Prostate cancer frequently recurs as castration-resistant prostate cancer (CRPC).

Purpose of the Study:

  • To review recent findings on androgen receptor (AR) signaling in CRPC.
  • To interpret the clinical behavior of CRPC after treatment.
  • To discuss molecular mechanisms of castration resistance.

Main Methods:

  • Literature review of experimental findings.
  • Analysis of AR-signaling pathways in CRPC.
  • Interpretation of clinical data for treatments like abiraterone and enzalutamide.

Main Results:

  • CRPC sustains AR signaling despite low androgen levels.
  • Multiple molecular mechanisms contribute to castration resistance.
  • Understanding AR signaling is crucial for effective CRPC treatment.

Conclusions:

  • AR signaling remains central to CRPC progression.
  • Newer therapies target AR signaling to overcome resistance.
  • Further research into AR pathways is essential for improved patient outcomes.
Keywords:
AR-point mutationsAR-variantsAbirateroneEnzalutamidePersonalized medicine

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