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Does kallikrein improve the brain function in dementia?

Y Ishizuka1, H Fukuzawa, T Asada

  • 1Department of Psychiatry, Yamanashi Medical College, Japan.

Advances in Experimental Medicine and Biology
|January 1, 1989
PubMed
Summary
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Kallikrein administration improved brain activity in multi-infarct dementia patients. Electroencephalogram (EEG) analysis showed increased alpha and beta waves, suggesting enhanced cerebral blood flow.

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Multi-infarct dementia is a debilitating condition affecting cognitive function.
  • Cerebral blood flow is crucial for maintaining brain health and function.

Purpose of the Study:

  • To investigate the effects of Kallikrein on electroencephalogram (EEG) patterns in patients with multi-infarct dementia.
  • To assess the potential of Kallikrein to improve cerebral blood flow.

Main Methods:

  • Nine patients with multi-infarct dementia received intramuscular Kallikrein (40 biological units).
  • EEG analysis using wave-form recognition was performed before and at multiple time points after administration (0, 30, 60, 90, 120 minutes).

Main Results:

  • A decrease in delta and theta brain waves was observed over time post-Kallikrein injection.

Related Experiment Videos

  • A corresponding increase in alpha and beta brain waves was noted.
  • These EEG changes suggest improved cerebral blood flow.

    • Conclusions:

    • Kallikrein administration appears to positively modulate EEG activity in multi-infarct dementia patients.
    • The observed EEG changes are likely due to Kallikrein-induced cerebral vasodilation and increased cerebral blood flow.