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Related Concept Videos

Thermosensation01:43

Thermosensation

35.5K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Thermoregulation01:26

Thermoregulation

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The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Body Temperature01:25

Body Temperature

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The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
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Body Temperature01:07

Body Temperature

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Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
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Diversity of Archaea IV01:29

Diversity of Archaea IV

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Hyperthermophilic archaea are a group of extremophiles thriving at temperatures above 80°C, often in hydrothermal vents and volcanic soils where conditions surpass the boiling point of water. At such temperatures, proteins, membranes, and DNA in most organisms degrade, but hyperthermophiles have evolved remarkable adaptations to maintain stability and function.Unique Cellular FeaturesHyperthermophilic membranes are composed of a monolayer of biphytanyl tetraether lipids, which resist...
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Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

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Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
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Updated: Apr 8, 2026

Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions
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Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions

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Thermosensation and longevity.

Rui Xiao1, Jianfeng Liu, X Z Shawn Xu

  • 1Life Sciences Institute and Department of Molecular and Integrative Physiology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI, 48109, USA.

Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
|June 24, 2015
PubMed
Summary
This summary is machine-generated.

Animals sense temperature using molecular thermosensors like TRP channels. Temperature actively regulates aging and longevity, not just passively, involving specific genes.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Molecular Biology

Background:

  • Animals possess sophisticated mechanisms to sense and adapt to environmental temperature fluctuations.
  • Thermosensation is mediated by molecular sensors, notably thermosensitive transient receptor potential (TRP) channels, found in various tissues.
  • While temperature's effect on behavior is well-studied in model organisms, its impact on aging is less understood.

Purpose of the Study:

  • To review current understanding of thermosensation.
  • To explore the role of thermosensation in aging processes.
  • To discuss how temperature actively regulates longevity.

Main Methods:

  • Review of existing literature on thermosensation and aging.
  • Analysis of studies in model organisms like Caenorhabditis elegans and Drosophila.
  • Focus on genetic regulation of temperature-modulated longevity.

Main Results:

  • Thermosensitive TRP channels are key molecular players in sensing temperature across a wide range.
  • Temperature influences aging and longevity through active, gene-regulated processes, challenging the rate-of-living theory.
  • Studies in C. elegans highlight the genetic control over temperature's effect on lifespan.

Conclusions:

  • Thermosensation is a critical biological process involving specialized molecular sensors.
  • Temperature actively modulates aging and longevity via genetic pathways, including TRP channels.
  • Further research into thermosensation's role in aging can reveal new insights into lifespan regulation.