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Scrub typhus associated hepatic dysfunction and abdominal CT findings
Man Je Park1, Hyoun Soo Lee2, Sang Goon Shim3
1Man Je Park, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Gyeongsangnam-do, Korea.
Pakistan Journal of Medical Sciences
|June 24, 2015
Summary
Scrub typhus often causes elevated aminotransferases. Abdominal CT scans reveal varied findings like enlarged lymph nodes and liver enhancement, aiding diagnosis in endemic regions.
Area of Science:
- Infectious Diseases
- Radiology
- Hepatology
Background:
- Scrub typhus is an infectious disease prevalent in endemic areas.
- Hepatic dysfunction is a common complication of scrub typhus.
Purpose of the Study:
- To investigate abnormal hepatic dysfunction and abdominal computed tomography (CT) findings in scrub typhus patients.
- To correlate laboratory findings with imaging results.
Main Methods:
- Retrospective analysis of 349 adult scrub typhus patients.
- Review of abdominal CT scans from 94 patients.
- Collection of clinical and laboratory data from electronic medical records.
Main Results:
- Elevated aspartate aminotransferase (78.5%) and alanine aminotransferase (63.0%) were the most common laboratory findings.
- Frequent abdominal CT findings included enlarged lymph nodes (53.2%), inhomogeneous liver enhancement (47.9%), and splenomegaly (46.8%).
- A correlation was observed between elevated aspartate aminotransferase levels and the number of CT findings (P=0.028).
Conclusions:
- Abdominal CT manifestations in scrub typhus with elevated aminotransferases are diverse and non-specific.
- Recognizing these imaging findings can assist clinicians in diagnosing scrub typhus in endemic areas.
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