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Glomerular diseases outcome at one year in a tertiary care centre
Huma Mamun Mahmud1, Darshan Kumar2, Humera Irum3
1Dr. Huma Mamun Mahmud, MBBS, MCPS (Med), FCPS (Nephrol). Assistant Professor, Consultant Nephrologist, Department of Medicine, Dow International Medical College, Dow University of Heath Sciences, Karachi, Pakistan.
Insights
A one-year follow-up is crucial for patients with glomerular diseases, especially those with stage 4 chronic kidney disease (CKD). Some patients may progress to end-stage renal failure within this timeframe.
Area of Science:
- Nephrology
- Internal Medicine
- Clinical Research
Background:
- Glomerular diseases represent a significant cause of kidney damage.
- Understanding disease progression is vital for patient management.
Purpose of the Study:
- To evaluate the one-year outcomes of patients with primary and secondary glomerular diseases.
- To identify factors influencing disease progression.
Main Methods:
- Observational cohort study conducted in an outpatient setting.
- Included patients with proteinuria and clinical signs of glomerular disease, excluding those with stage 5 CKD.
- Follow-up assessed proteinuria and renal insufficiency over one year.
Main Results:
- 173 patients completed the one-year follow-up.
- Diabetic nephropathy (94.2%) and hypertension (66.5%) were the most common conditions.
- Four patients (2.3%) progressed to stage 5 CKD; proteinuria levels remained stable.
Conclusions:
- One-year follow-up is critical for patients with glomerular disease and stage 4 CKD.
- Progression to end-stage renal failure can occur within one year in this cohort.
Objectives:
To determine outcome in primary and secondary glomerular diseases at one year follow up.
Methods:
Study design is observational cohort, done in out-patient department, Dow Iinternational Medical College, DUHS. All information gathered on a proforma. All patients with dipstick positive proteinuria and clinical glomerular disease were included in study. Patients with no proteinuria were excluded so were patients with stage 5 CKD. Patients were followed for proteinuria and renal insufficiency at completion of one year follow up. Statistical analysis was done on SPSS version 16.
Result:
Total number of patients who completed one year follow up was 173. Mean age of patients was 51.67+ 10.16 (range 15 to 75 years). Ninety two (53.2%), were males and 81(46.8%) were females, ratio being 1.1: 1.0. Mean weight of our patients was 67.43+ 14.13 Kg, (35 to 107 kg). Commonest cause of glomerular disease in our patient was diabetic nephropathy which was seen in 94.2% patients. Commonest associated problem with glomerular disease was hypertension seen in 66.5% of patients. Four out of 173 patients had stage 5 CKD at end of follow up at one year while quantitativ proteinuria remained same at one year follow up.
Conclusion:
One year follow up is critical for patients with glomerular disease associated with stage 4 CKD as progression to end stage renal failure may be seen within one year in these patients.
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