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Updated: Apr 8, 2026

Daily Transfers, Archiving Populations, and Measuring Fitness in the Long-Term Evolution Experiment with Escherichia coli
Published on: August 18, 2023
From Here to Eternity--The Theory and Practice of a Really Long Experiment
Jeremy W Fox1, Richard E Lenski2
1Department of Biological Sciences, University of Calgary, Calgary, Canada.
Abstract:
In February 1988, Richard Lenski set up 12 replicate populations of a single genotype of Escherichia coli in a simple nutrient medium. He has been following their evolution ever since. Here, Lenski answers provocative questions from Jeremy Fox about his iconic "Long-Term Evolution Experiment" (LTEE). The LTEE is a remarkable case study of the interplay of determinism and chance in evolution-and in the conduct of science.
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