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Related Concept Videos

Coagulation01:09

Coagulation

12.1K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Coagulation01:06

Coagulation

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

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Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
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Related Experiment Video

Updated: Apr 8, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Fluids and coagulation.

Sibylle A Kozek-Langenecker1

  • 1aSigmund Freud Private University Vienna bDepartment of Anesthesia and Intensive Care, Evangelical Hospital Vienna, Vienna, Austria.

Current Opinion in Critical Care
|June 24, 2015
PubMed
Summary

Infusion therapy can cause dilutional coagulopathy, affecting blood clotting. Risk varies by fluid type, necessitating careful monitoring and potential fibrinogen concentrate use in severe cases.

Area of Science:

  • Anesthesiology
  • Critical Care Medicine
  • Hematology

Background:

  • Infusion therapy is crucial for managing hypovolemia and fluid deficits.
  • Both crystalloid and colloid solutions can impact blood coagulation.
  • The clinical significance of fluid-induced coagulopathy remains a key question.

Purpose of the Study:

  • To review the pathomechanisms of dilutional coagulopathy.
  • To assess the clinical relevance of fluid-induced coagulopathy in perioperative and critically ill patients.
  • To discuss medicolegal aspects related to infusion therapy and coagulopathy.

Main Methods:

  • Review of existing literature on dilutional coagulopathy.
  • Analysis of evidence for clinical relevance in specific patient populations.

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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

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Microfluidics in Assessing Platelet Function
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Last Updated: Apr 8, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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  • Discussion of monitoring techniques and treatment strategies.

    • Main Results:

    • The risk of dilutional coagulopathy is dose-dependent and varies significantly between different colloid solutions (e.g., dextran > hetastarch).
    • Rotational thromboelastometry/thrombelastography can assess clot strength, formation, and platelet interaction.
    • Fibrinogen concentrate may be considered for severe bleeding and coagulopathy.
    • Certain colloids like gelatins and tetrastarches show no proven adverse effects on anemia or blood transfusions.

    Conclusions:

    • Awareness of dilutional coagulopathy risks and early monitoring are essential.
    • Fluid-induced coagulopathy can be clinically relevant, impacting patient outcomes and resource use.
    • Targeted fluid selection and potential interventions like fibrinogen concentrate can mitigate risks.