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Updated: Apr 8, 2026

An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells
Published on: August 15, 2012
[Malaria and HIV: which interactions?]
Abstract:
People living with HIV (PLHIV) frequently travel, including to the tropics, with a variable risk of infection by one of the species of Plasmodium, the hemoprotozoan parasite responsible for malaria. The HIV-malaria co-infection increases the risk of severe malaria, in proportion to the degree of immunosuppression. Protective measures against mosquito bites and antimalarial drug prophylaxis are recommended for PLHIV travelling to malaria highly endemic areas. PLHIV, as compared to the general population, are less likely to attend a pre-travel consultation prior to departure. Among returning travelers with malaria, early diagnosis and artemisinin-based treatments are the main determinants of successful treatment outcome.
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