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Updated: Apr 8, 2026
Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
Published on: March 15, 2019
High-Throughput DNA Sequencing Analysis of Antibody Repertoires
Scott D Boyd1, Shilpa A Joshi1
1Department of Pathology, Stanford University, Stanford, CA 94305.
Abstract:
New high-throughput DNA sequencing (HTS) technologies developed in the past decade have begun to be applied to the study of the complex gene rearrangements that encode human antibodies. This article first reviews the genetic features of Ig loci and the HTS technologies that have been applied to human repertoire studies, then discusses key choices for experimental design and data analysis in these experiments and the insights gained in immunological and infectious disease studies with the use of these approaches.
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