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Updated: Apr 8, 2026
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
sFlt-1 and IP-10 in women with early-onset preeclampsia
Leandro De Oliveira1, Niels Olsen S Câmara2, José C Peraçoli3
1Obstetrics Department, Universidade Federal de São Paulo, Brazil; Laboratory of Immunobiology of Transplantation, Universidade de São Paulo, Brazil; Laboratory of Clinical and Experimental Investigation, Hospital e Maternidade Vila Nova Cachoeirinha, São Paulo, Brazil.
Abstract:
Intense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5pg/mL in preeclamptic women, as compared with 52.28pg/mL in the controls (P=0.0028). The mean serum level of sFlt-1 was 13,636pg/mL in preeclamptic women, as compared with 2020pg/mL in the controls (P<0.0001). PlGF levels were significantly lower in women with preeclampsia.
