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Updated: Apr 8, 2026
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
S100B brain expression and plasma concentrations in a preeclampsia rat model
M N van Ijsselmuiden1, M J Wiegman1, G G Zeeman1
1Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, The Netherlands.
Objective:
To assess brain damage using the neuroinflammation marker S100B in a preeclampsia rat model.
Methods:
Non-pregnant and pregnant rats were infused with saline or low-dose-endotoxin on day 14 of pregnancy. S100B expression in the brain (immunohistochemistry) and S100B plasma concentrations (ELISA) were studied.
Results:
No differences in S100B expression in brain tissue were observed between the four groups. Pregnant endotoxin treated animals did not show increased levels of plasma S100B levels as compared with control pregnant rats, while significantly higher plasma S100B levels were found in non-pregnant endotoxin versus pregnant endotoxin infused rats.
Conclusion:
Pregnancy nor experimental preeclampsia, alter S100B in rat brain, or in plasma. Increased plasma S100B in non-pregnant endotoxin-treated rats may indicate brain injury in these rats, whereas pregnancy might be protective.
