Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Drug-induced nephropathies].

J P Fillastre1, M Dhib, M Godin

  • 1Service de Néphrologie, Hôpital de Bois-Guillaume.

Annales De Medecine Interne
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytokine release syndrome-associated encephalopathy in patients with COVID-19.

European journal of neurology·2020
Same author

Global Transplantation COVID Report March 2020.

Transplantation·2020
Same author

Torquetenovirus viremia for early prediction of graft rejection after kidney transplantation.

The Journal of infection·2019
Same author

Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Intraoperative Pleth Variability Index Is Linked to Delayed Graft Function After Kidney Transplantation.

Transplantation proceedings·2016
Same author

Predictive Modeling of Tacrolimus Dose Requirement Based on High-Throughput Genetic Screening.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016

The kidneys are highly susceptible to drug toxicity due to their unique functions, leading to various forms of kidney damage. French nephrologists identified key factors contributing to drug-induced kidney injury.

Area of Science:

  • Nephrology
  • Pharmacology
  • Toxicology

Context:

  • The kidneys' physiological characteristics, including high blood flow, extensive surface area, active transport mechanisms, metabolic activity, and concentrating ability, render them vulnerable to drug-induced damage.
  • Nephrotoxic agents can impact all renal structures (glomeruli, tubules, interstitium, vessels) and manifest as acute renal failure or tubule necrosis.
  • The study's focus was determined by a survey of French nephrologists regarding nephrotoxic drug effects.

Purpose:

  • To elucidate the reasons behind the kidney's particular susceptibility to nephrotoxic drugs.
  • To categorize the diverse pathological effects of nephrotoxins on renal structures.
  • To establish the scope of a focused discussion on drug-induced kidney injury based on expert opinion.

Summary:

Related Experiment Videos

  • The kidneys' unique functional properties facilitate exposure to and concentration of drugs, increasing the risk of nephrotoxicity.
  • Drug-induced kidney injury can range from functional alterations causing acute renal failure to cellular necrosis, affecting various nephron components.
  • A survey of French nephrologists guided the selection of specific topics within the broad field of nephrotoxic drug actions.

Impact:

  • Understanding these vulnerabilities aids in predicting and preventing drug-induced kidney injury.
  • This knowledge supports the development of safer prescribing practices and therapeutic strategies.
  • The findings provide a foundation for further research into specific nephrotoxic mechanisms and interventions.