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Updated: Apr 8, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Maternal hypertensive diseases negatively affect offspring motor development.

Tegan Grace¹, Max Bulsara², Craig Pennell³

¹School of Health Sciences, University of Notre Dame Australia, Australia.

Pregnancy Hypertension

|June 25, 2015

Summary

Maternal hypertensive diseases, especially preeclampsia, during pregnancy negatively impact offspring motor development. These effects persist into late childhood and adolescence, indicating long-term consequences.

Keywords:

Adolescence Hypertension Motor development Preeclampsia Raine Study

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Published on: May 5, 2018

Area of Science:

Developmental neuroscience
Maternal-fetal medicine
Pediatric neurology

Background:

Hypertension in pregnancy and preeclampsia are associated with adverse developmental outcomes in offspring.
Limited longitudinal research exists on the long-term effects of maternal hypertensive disorders on offspring motor development.

Purpose of the Study:

To investigate if maternal hypertensive diseases during pregnancy are a risk factor for compromised motor development in offspring.
To assess motor development at ages 10, 14, and 17 years in relation to maternal pregnancy blood pressure.

Main Methods:

Utilized data from the Western Australian Pregnancy Cohort Study (Raine), a longitudinal cohort study.
Classified 2868 offspring based on maternal blood pressure: normotension, hypertension, and preeclampsia.
Measured offspring motor development using the Neuromuscular Developmental Index (NDI) of the McCarron Assessment of Motor Development (MAND) at ages 10, 14, and 17.
Employed linear mixed models for statistical analysis to compare motor outcomes between groups.

Main Results:

Offspring exposed to preeclampsia in utero exhibited significantly poorer motor development across all measured ages compared to normotensive groups (p≤0.001).
Offspring of mothers with hypertension also showed poorer motor outcomes than those from normotensive pregnancies (p=0.002).

Conclusions:

Hypertensive disorders of pregnancy, particularly preeclampsia, are associated with lasting deficits in offspring motor development.
These findings suggest that preeclampsia may have permanent consequences for motor function in children and adolescents.