Related Experiment Video

Updated: Apr 8, 2026

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

16.6K

The role of oxidative stress in the pathogenesis of pre-eclampsia

S Sulistyowati1

  • 1Fetomaternal Division Obstetrics and Gynaecology Department, Sebelas Maret University/ Dr. Moewardi Hospital, Indonesia.

Pregnancy Hypertension
|June 25, 2015
PubMed

Insights

Preeclampsia, a pregnancy disorder, involves complex multisystem issues. Oxidative stress and antioxidant imbalance are key factors in its pathophysiology, impacting maternal and fetal health.

Area of Science:

  • Obstetrics and Gynecology
  • Pathophysiology
  • Maternal-Fetal Medicine

Background:

  • Preeclampsia is a pregnancy-specific disorder causing significant maternal and fetal mortality and morbidity.
  • The precise pathogenesis of preeclampsia remains a significant challenge in medical research.
  • Oxidative stress is increasingly recognized as a primary contributor to preeclampsia's development.

Purpose of the Study:

  • To elucidate the role of oxidative stress in the pathophysiology of preeclampsia.
  • To investigate the link between abnormal placentation and oxidative damage.
  • To understand the imbalance in antioxidant defense mechanisms in preeclampsia.

Main Methods:

  • Review of current literature on preeclampsia pathophysiology.
  • Analysis of studies investigating oxidative stress markers.
  • Examination of research on placental dysfunction and ischemia.

Main Results:

  • Oxidative stress contributes to reduced blood perfusion and ischemia, leading to abnormal placentation.
  • Oxidative damage and a compromised antioxidant defense system are central features of preeclampsia.
  • These pathways are extensively studied and acknowledged in recent years.

Conclusions:

  • Oxidative stress and antioxidant imbalance are critical components in the pathophysiology of preeclampsia.
  • Understanding these mechanisms is vital for addressing maternal and fetal complications.
  • Further research into these pathways may reveal new therapeutic targets.

Keywords:
Oxidative stressPreeclampsia

More Related Videos

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K
Analysis of Oxidative Stress in Zebrafish Embryos11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

38.5K

Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
37.2K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.2K
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
22.2K
Peroxisomes01:24

Peroxisomes

2.0K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.5K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
998