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Related Experiment Videos

[Interactions between prolactin with its receptor].

P Jaquet1, I Pellegrini

  • 1Laboratoire d'Endocrinologie Expérimentale, INSERM U 297, Faculté de Médecine Nord, Marseille.

Annales D'Endocrinologie
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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The prolactin (PRL) receptor

Area of Science:

  • Endocrinology and Molecular Biology
  • Cellular and Molecular Physiology

Context:

  • The prolactin (PRL) receptor, a key mediator of PRL signaling, has been recently sequenced.
  • Understanding the PRL receptor's structure and function is crucial for deciphering PRL's diverse biological roles.

Purpose:

  • To review the current understanding of the prolactin receptor's structure, regulation, and signaling mechanisms.
  • To highlight recent findings regarding different molecular forms of PRL and their implications for receptor interaction.

Summary:

  • The rat PRL receptor is a 291-amino acid glycosylated polypeptide, primarily located on the cell membrane.
  • Larger PRL receptor forms with homology to growth hormone receptors exist in other species.
  • PRL regulates its own receptor number, with complex interactions involving various PRL molecular forms.

Related Experiment Videos

Impact:

  • Advances in understanding PRL receptor heterogeneity may reveal new therapeutic targets for PRL-related conditions.
  • Elucidating PRL signaling pathways can provide insights into reproductive physiology, lactation, and disease states.