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Calcium-to-creatinine ratio in pregnancy-induced hypertension

Rose Gasnier¹, Edimárlei Gonsales Valério², Janete Vettorazzi²

¹Post-Graduate Program in Medicine: Medical Sciences, Brazil.

Pregnancy Hypertension

|June 25, 2015

Objectives:

Hypocalciuria has been correlated with preeclampsia. This study compared the calcium-to-creatinine ratio among the groups, and the correlation with the 24-h measurement of this ratio and a diagnosis of preeclampsia.

Study Design:

Case-control study including mild and severe preeclampsia, chronic hypertension and normal pregnancy.

Main Outcome Measurements:

The calcium-to-creatinine ratio differentiates severe preeclampsia from mild preeclampsia, chronic hypertension and normal pregnancy.

Results:

There were statistically significant differences between the groups when comparing severe preeclampsia and chronic hypertension, severe preeclampsia and normal pregnancy, and mild and severe preeclampsia (p<0.0001). The Spearman index between the calcium-to-creatinine ratio and 24-h calciuria was 0.65 (high correlation).

Conclusions:

The calcium-to-creatinine ratio can reliably estimate 24-h calciuria, differentiating severe preeclampsia from mild preeclampsia, chronic hypertension and normal pregnancy.

Keywords:

Calcium-to-creatinine ratio High-risk pregnancy Hypocalciuria Preeclampsia Pregnancy hypertension

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