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Serum S100B in pregnancy complicated by preeclampsia: A case-control study
J Vettorazzi1, F V Torres2, T T de Ávila2
1Department of Obstetrics and Gynecology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035, Brazil.
Pregnancy Hypertension
|June 25, 2015
Summary
Elevated serum S100B protein levels in severe preeclampsia indicate neural damage. This suggests astrocytic release of S100B occurs independently of preeclampsia progression to eclampsia.
Area of Science:
- Neurology
- Obstetrics
- Biochemistry
Background:
- Serum S100B protein is primarily released by astrocytes in the Central Nervous System (CNS).
- Elevated S100B levels are linked to various brain pathologies, including eclampsia in pregnant women.
Purpose of the Study:
- To compare serum S100B concentrations in pregnant women with severe and mild preeclampsia (PE) against normotensive pregnant women.
Main Methods:
- Serum S100B levels were measured using a luminometric assay.
- Participants included normotensive pregnant women (n=15), women with mild PE (n=12), and women with severe PE (n=34).
Main Results:
- Sixty-one women were studied, with a mean age of 26.6 years and gestational age of 33.3 weeks.
- Severe PE group showed significantly higher S100B levels (0.20±0.19 μg/L) compared to mild PE (0.07±0.05 μg/L) and normotensive groups (0.04±0.05 μg/L).
Conclusions:
- Higher serum S100B in severe PE suggests neural damage.
- Astrocytic release of S100B in severe PE may not depend on progression to eclampsia.
