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Palliative parenteral nutrition use in patients with intestinal failure as a consequence of advanced pseudomyxoma

B R Disney1, A Karthikeyakurup1, J Ratcliffe1

  • 1Department of Gastroenterology, Russells Hall Hospital, Dudley Group NHS Foundation Trust, Dudley, UK.

European Journal of Clinical Nutrition
|June 25, 2015
PubMed

Insights

Parenteral nutrition (PN) can be safely used in select patients with advanced pseudomyxoma peritonei (PMP) and intestinal failure. Careful patient selection and timing are crucial for successful palliative PN initiation.

Area of Science:

  • Oncology
  • Gastroenterology
  • Palliative Care

Background:

  • Pseudomyxoma peritonei (PMP) is a rare malignancy characterized by intra-abdominal spread.
  • PMP can lead to multilevel gastrointestinal (GI) obstruction and intestinal failure.
  • The role of parenteral nutrition (PN) in palliative care for advanced malignancy is debated.

Observation:

  • This study describes the palliative use of PN in three patients with progressive PMP.
  • All patients experienced multilevel GI obstruction and intestinal failure due to PMP.
  • Patients received PN for over 90 days.

Findings:

  • Palliative PN was found to be safe in this cohort of patients with PMP.
  • No major complications directly related to PN were reported.
  • The study highlights the feasibility of long-term PN in this challenging patient group.

Implications:

  • PN can be a viable option for managing intestinal failure in advanced PMP.
  • Judicious patient selection and appropriate timing of PN initiation are critical for optimal outcomes.
  • Further research is warranted to establish clear guidelines for PN use in palliative oncology.

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