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OS050. Genetic variants in pre-eclampsia: a meta-analysis.

A Buurma1, R Turner1, A Driessen2

  • 1Pathology, Leiden University Medical Center, Leiden, Netherlands.

Pregnancy Hypertension
|June 25, 2015
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Summary
This summary is machine-generated.

This study identified 8 genetic variants reproducibly associated with preeclampsia, primarily in the renin-angiotensin and coagulation systems. These findings suggest shared genetic risk factors between preeclampsia and cardiovascular disease.

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Area of Science:

  • Genetics
  • Obstetrics
  • Cardiovascular Medicine

Background:

  • Preeclampsia exhibits a familial component, indicating a potential genetic susceptibility.
  • Numerous genetic association studies exist, but replication has been inconsistent.
  • This meta-analysis focuses on reproducibly associated genetic variants in preeclampsia.

Purpose of the Study:

  • To provide an overview of genetic variants reproducibly linked to preeclampsia.
  • To consolidate findings from multiple genetic association studies.

Main Methods:

  • A systematic literature search was conducted in PubMed, EMBASE, and Web of Science.
  • Genetic variants significantly associated in an initial study and reproduced in at least one other study were selected.
  • Pooled odds ratios were calculated at the allele level for the association between variants and preeclampsia.

Main Results:

  • 542 genetic association studies on preeclampsia were identified from 2965 citations.
  • 23 genetic variants were found to be replicated.
  • A random-effects meta-analysis confirmed 8 variants significantly associated with preeclampsia, located in or near ACE, AGT, CTLA4, F2, FV (two variants), LPL, and SERPINE1 genes.

Conclusions:

  • Eight genetic variants are associated with preeclampsia, predominantly in the renin-angiotensin and coagulation systems.
  • Shared genetic risk factors between preeclampsia and cardiovascular disease are indicated.
  • Future research should explore the role of these identified genes in preeclampsia pathogenesis.