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OS082. CHIPS-Child: Testing the developmental origins hypothesis.

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This summary is machine-generated.

This study investigates how different blood pressure controls during pregnancy affect infant development. Findings will reveal if tighter blood pressure management impacts fetal programming and long-term health outcomes.

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Area of Science:

  • Developmental biology
  • Maternal-fetal medicine
  • Epigenetics

Background:

  • Reduced fetal growth is linked to adult cardiovascular risks, independent of birth weight.
  • The Developmental Origins of Health and Disease (DOHaD) hypothesis suggests in-utero changes permanently alter fetal genome.
  • These adaptive in-utero changes may become maladaptive postnatally.

Purpose of the Study:

  • To investigate if differential blood pressure (BP) control in pregnancy causes developmental programming effects in offspring, independent of birth weight.
  • To test the hypothesis that tighter maternal BP control leads to fetal under-nutrition and developmental programming.
  • To examine the impact of maternal BP management on infant health outcomes.

Main Methods:

  • CHIPS-Child is an ancillary study to the CHIPS randomized controlled trial (RCT) comparing 'tight' (dBP 85mmHg) vs. 'less tight' (dBP 100mmHg) BP control.
  • Offspring are assessed non-invasively at 12 months corrected age for anthropometry, hair cortisol, and epigenetic markers (DNA methylation).
  • Longitudinal follow-up includes annual measurements of height, weight, and waist circumference until age 5.

Main Results:

  • Primary outcome: difference in early postnatal weight gain (change in z-score for weight) between birth and 12 months.
  • Secondary outcomes include hypothalamic-pituitary-adrenal axis function (hair cortisol) and DNA methylation patterns.
  • Analysis will compare outcomes between infants born to mothers with different BP control strategies.

Conclusions:

  • CHIPS-Child provides a unique human model to study developmental programming effects of differential BP control in pregnancy.
  • The study will enhance understanding of human biology and diversity related to prenatal environmental influences.
  • Findings will clarify the long-term consequences of maternal BP management on offspring health.