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OS088. First trimester triple vascular test for pre-eclampsia prediction
J A Gurgel Alves1, S P Brennecke2, F da Silva Costa2
1Department of Public Health, State University of Ceara, Fortaleza, Brazil.
Pregnancy Hypertension
|June 25, 2015
Summary
Early preeclampsia (PE) detection is improved by combining maternal factors, mean arterial pressure, and ophthalmic artery Doppler. This approach offers a significant advancement in predicting early-onset PE, enhancing maternal and fetal health outcomes.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Cardiovascular Physiology
Background:
- Preeclampsia (PE) is a leading cause of maternal and fetal mortality, with unclear vascular mechanisms.
- Early detection of PE remains a challenge, necessitating evaluation of early pregnancy maternal circulation changes.
Purpose of the Study:
- To assess the predictive value of combining maternal risk factors, mean arterial pressure, uterine artery Doppler, brachial artery flow-mediated dilatation (FMD), and ophthalmic artery Doppler for PE in the first trimester.
Main Methods:
- Prospective study of 487 singleton pregnancies at 11-14 weeks gestation.
- Collected data included maternal history, BMI, MAP, uterine artery PI, brachial artery FMD, and ophthalmic artery Doppler.
- Logistic regression analysis was used to develop prediction algorithms for hypertensive disorders.
Main Results:
- Ophthalmic artery Doppler showed higher velocities in the PE group (p<0.01).
- Brachial artery FMD was not a significant predictor of PE (p=0.90).
- A predictive model combining maternal factors + MAP + uterine artery Doppler or ophthalmic artery Doppler detected 78% of early-onset PE with a 10% false-positive rate.
Conclusions:
- Maternal ophthalmic artery Doppler in the first trimester is a novel and effective predictor for early-onset PE.
- Its predictive contribution is comparable to uterine artery Doppler within a multi-parameter model.
