[Effect of antibiotics on excretion of various microbial metabolites with feces]

Concentrations of volatile fatty acids, free amino acids, ammonia, protein, carbohydrates, carboxylic acids and some cations were determined in feces of intact animals (rats) chromatographically and spectroscopically. Oral administration of 8 chemotherapeutic drugs in the therapeutic doses to the animals resulted in changing excretion of the majority of the above compounds associated with vital activity of the large intestine microflora which depended on the drug type. Investigation of metabolic activity of normal microflora of the gastrointestinal tract is shown promising for estimation of intestinal microbial biocenosis.