PP034. Cardiovascular outcomes remote from pregnancy in women with HDP: 23-32years following delivery

Cardiovascular disease (CVD) is a leading cause of mortality worldwide in women aged >54years. There is a strong association between HDP and the development of hypertension in later life.

To ascertain the current health profile of some of the women who were diagnosed with a HDP and participated in a trial during the time period of 1980-1989 and to examine the association between the two.

Women who delivered at a major teaching hospital during the designated time period and who were enrolled at that time in trials examining HDP treatments and outcomes were invited to participate in a health status evaluation. Their medical histories, time sequenced blood pressure readings, urinalysis, BMI and pulse wave analysis were compared using standard statistical techniques of Chi-square analysis and Student's t-tests obtained from IBM SPSS v.19™.

Thirty-nine women from the trials were available for follow-up. Of these women, 85% had current CVD, of which 88% had hypertension, 59% hypercholesterolaemia and 3% had experienced a CVA. Compared to the general female population of 22% for CVD this equates to a RR of 7.2 (CI 95% 3.042-15.13).

HDP is associated with an increased risk of CVD compared to the general female population. Women who experience HDP in their pregnancy should be monitored regularly due to an increased risk of CVD and potentially early onset of the disease.