PP107. Cardiovascular parameters 40 years after hypertensive pregnancies.

Area of Science:

• Cardiovascular Medicine
• Obstetrics
• Endocrinology

Background:

• Epidemiological studies link hypertensive pregnancies to increased long-term cardiovascular risk in women.
• Mechanisms underlying this elevated risk remain incompletely understood.
• Few clinical investigations have explored the long-term cardiovascular, metabolic, and neuroendocrine status of these women.

Purpose of the Study:

• To investigate potential cardiovascular, metabolic, and neuroendocrine status deterioration in women 40 years post-hypertensive pregnancies.
• To identify if specific biomarkers or clinical parameters are altered decades after pregnancy complications.

Main Methods:

• A follow-up study involving 105 women (50 with prior hypertensive pregnancies (HTP), 55 with normotensive pregnancies (NTP)) 40 years postpartum.
• Assessment included office and ambulatory blood pressure, central hemodynamics (pulse wave velocity), echocardiography (cardiac structure and function), and extensive blood analyses (metabolic, inflammatory, neurohormonal markers).
• A questionnaire assessed cardiovascular health in non-participants (n=214).

Main Results:

• No significant differences were found in blood pressure, echocardiographic parameters, or blood analyses between HTP and NTP groups.
• Hypertension was diagnosed in 25 HTP participants and 17 NTP participants.
• Questionnaire data suggested impaired cardiovascular health in women who did not participate in the clinical investigation.

Conclusions:

• Long-term hypertensive pregnancies do not invariably lead to worsened cardiovascular, metabolic, or neuroendocrine parameters 40 years later.
• Significant individual disparities exist within the HTP group.
• Some women remain without evident cardiovascular or metabolic dysfunction decades after hypertensive pregnancy events.