PP132 Comparison between Early-onset and Late-onset Preeclampsia based on maternal cardiac output, Total Peripheral...

Earlier report show different maternal hemodynamic and uterine artery profile at early gestational ages between pregnant women that will develop Early-onset and Late onset Preeclampsia (PE) later.

The aim of this study is to compare maternal hemodynamic (Cardiac Output, Total Peripheral Vascular Resistance) and Uterine Perfusion (Uterine Artery Resistance Index) profile during onset of the disease between Early and Late-onset Preeclampsia.

A cross-sectional observational analytic study of 17 severe PE and 20 matched controls. The PE group was divided into early onset PE (<34weeks) and late onset PE (>34weeks). We examine doppler velocimetry ultrasound and echocardiography in 1-2days after the patient admitted to hospital. Primary outcome included uterine artery resistance index (UARI), cardiac output (CO), and total peripheral vascular resistance value (TVR).

We found no significant difference of uterine artery resistance index value between early onset PE (0.68±0.079) and control (0.67±0.093) (p=0.620); late-onset PE (0.67±0.142) and control (0.67±0.084) (p=0.959). Maternal hemodynamic profile show Early-onset PE CO (6.06±1.172L/m) was higher than control (4.67±1.739L/m) (p=0.079), and TVR (1.76±0.434dynes.s/cm(5)) was higher than control (1.58±0.498dynes.s/cm(5)) (p=0.481). Late onset PE show similar result, CO (5.17±1.433L/m) was higher than control (4.47±1.649L/m) (p=0.467) and TVR (2.29±0.796dynes.s/cm(5)) was also higher than control (1.82±0.947dynes.s/cm(5)) (p=0.527).

Maternal hemodynamic of Early onset and Late onset PE seem to have a complex process that cannot be differentiate strictly based on gestational ages, and the view that those two disease came from a different etiology should be reconsidered.