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PP160. Endothelial dysfunction with obesity, pregnancy and preeclampsia
1Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, United States.
Pregnancy Hypertension
|June 25, 2015
Summary
Preeclampsia is linked to higher sE-selectin levels, indicating endothelial dysfunction. However, obesity did not show increased sE-selectin, suggesting it may not be the primary driver of endothelial dysfunction in preeclampsia.
Area of Science:
- Obstetrics and Gynecology
- Cardiovascular Research
- Maternal-Fetal Medicine
Background:
- Preeclampsia is a significant global cause of maternal and fetal mortality.
- Obesity is a known risk factor for preeclampsia, but the underlying mechanisms are unclear.
- Endothelial dysfunction is implicated in both preeclampsia and obesity, with sE-selectin as a potential marker.
Purpose of the Study:
- To investigate the relationship between sE-selectin concentrations, preeclampsia status, body mass index (BMI), and delivery status (preterm/term).
- To determine if increased sE-selectin in obese patients explains obesity's role as a preeclampsia risk factor.
Main Methods:
- A retrospective case-control study involving 91 Caucasian women.
- Serum sE-selectin levels were measured using enzyme-linked immunosorbent assay (ELISA).
- Participants were categorized by preeclampsia status, BMI (obese/lean), and delivery status (preterm/term).
Main Results:
- sE-selectin concentrations were significantly higher in women with preeclampsia compared to controls (p<0.05).
- Lean preterm preeclamptic women had higher sE-selectin than obese preterm preeclamptic women (p=0.04).
- No significant effect of BMI on sE-selectin levels was observed in other groups.
Conclusions:
- Elevated sE-selectin confirms increased endothelial dysfunction in preeclampsia.
- Increased sE-selectin is not associated with obesity in this cohort.
- Endothelial dysfunction, as measured by sE-selectin, does not explain the link between obesity and preeclampsia.
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