PP161. Association of maternal vitamin D and placenta growth factor with early-onset severe preeclampsia

Decreased maternal 25-hydroxy vitamin D (25-OH-D) and placenta growth factor (PlGF) have both been associated with the diagnosis of early-onset severe preeclampsia (EOSPE). Prior investigations have identified these biomarkers to be decreased at the time of diagnosis of preeclampsia and prior to the onset of clinical diagnosis of preeclampsia.

This investigation aimed to define the association of these biomarkers with EOSPE. This will yield information concerning possible potential for these biomarkers to be used in diagnosis of preeclampsia.

Patients with EOSPE and healthy controls were recruited and demographics, outcomes, and plasma were collected at matched gestational age. 25-OH-D was assessed by radioimmunoassay and reported in ng/mL. PlGF was assessed by ELISA and reported in pg/mL. Receiver operator curves were constructed for each regression model and sensitivity and specificity were reported for each biomarker.

In EOSPE, both 25-OH-D and PlGF were decreased significantly compared to controls. The combination of age, race, and PlGF or 25-OH-D performed well in discrimination of EOSPE and controls. The logistic regression model using both PlGF and 25-OH-D is shown below:

PlGF and 25-OH-D are sensitive and specific markers for diagnosis of EOSPE. However, PlGF provided a higher sensitivity and specificity for EOSPE diagnosis.