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PP172. Indian scenario of preeclampsia and its consequences and early prophylaxis
1Obstetrics and Gynaecolgy, Jariwala Womens Hospital, Ahmedabad, India.
Insights
Jariwala's therapy shows promise in managing mild to moderate preeclampsia, leading to positive birth outcomes. This approach avoids traditional antihypertensives, potentially improving placental function and reducing complications.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Perinatology
Background:
- Preeclampsia is a significant global obstetric challenge, particularly in developing nations.
- The exact etiology of preeclampsia remains elusive, necessitating novel prevention and treatment strategies.
- Current understanding of preeclampsia pathogenesis requires further investigation to refine management protocols.
Purpose of the Study:
- To evaluate the efficacy of Jariwala's therapy for preeclampsia.
- To explore the etiological factors contributing to preeclampsia development.
- To establish an improved prophylactic management strategy for preeclampsia.
Main Methods:
- A cohort of 800 pregnant individuals with preeclampsia was enrolled.
- Prediction of preeclampsia involved the roll-over test, color Doppler, and monitoring weight gain/edema.
- Jariwala's protocol was implemented for early intervention to mitigate disease severity.
Main Results:
- Jariwala's therapy demonstrated effectiveness in mild to moderate preeclampsia cases.
- 98% of neonates weighed 2kg or more at delivery.
- 92% of neonates were discharged directly home without complications and exhibited healthy development.
Conclusions:
- Antihypertensive treatment during pregnancy may lead to intrauterine growth restriction and rebound hypertension.
- Fetal and placental toxins may increase placental permeability, causing protein loss and multi-system dysfunction.
- Jariwala's protocol offers an alternative to routine treatment, with pregnancy termination reserved for severe, rapidly progressing cases.
Introduction:
Preeclampsia remains one of the major obstetrical problems in less-developed countries. The causes of this condition are still unknown, we have designed a prevention protocol with new concept to describe the etiology and cause of preeclampsia.
Objectives:
To study the effectiveness of the Jariwala's therapy and etiological causes of preeclapsia. we want to establish the new version of efficient prophylactic management to prevent the concequences of preeclampsia.
Methods:
We have selected 800 cases who have developed preeclampsia during any phase of pregnancy and tried to prevent the developing preeclampsia (predicted with roll over test, color doppler and weight gain and or edema) by Jariwala's protocol. our aim is to reduce the severity of disease process by early prediction and treatment. we have not included the cases who may have completely treated after the inclusion criteria to predict the preclampsia and treated. the inclusion criteris is strictly followed by a protocol designed.
Results:
Jariwala's therapy is effective in mild to moderate cases of preeclampsia. Till date we have successfully treated 800 cases of mild to moderate preeclapsia with 98% neonates delivered with birth weight of 2kg and more, 92% neonates sent directly to home without any complication; and developed well at home.
Conclusion:
If we try to treat the blood pressure (during pregnancy) by anti hypertensive we have noticedà IUGR and rebound increase of blood pressure, means decrease maternal blood pressure à decrease placental supplyà deficient nutrientà rebound increase in toxin secretion (by fetus and placenta) à increase in blood pressure to supply more nutrient). So that it is my suggestion that the antihypertensive should be avoided if possible 2: increase permeability of placental membranes due to toxins secreted by fetus to supply more nutrient leads to increase permeability of placental membranes means increase protein loss from kidneys (due to toxins secreted from the fetus and placenta) increase third space leakage of fluid as nutrient leads to serum protein deficiency and increase permeability of endovascularities of all organs multi system disorder. so instead of treating the developing preeclampsia with routine treatment either terminate the pregnancy if it is severe and developing intensely or treat with the Jariwala's protocol.
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