Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.9K
Hormonal Regulation01:33

Hormonal Regulation

37.2K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
37.2K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

17.1K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
17.1K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

119
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
119
Genetic Lingo01:11

Genetic Lingo

118.4K
Overview
118.4K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

88
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
88

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender differences in melanoma awareness, diagnosis and treatment: Patient-reported data from a multicentre survey in Switzerland.

Skin health and disease·2024
Same author

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

Nature communications·2020
Same author

Differences in the Postprandial Release of Appetite-Related Hormones Between Active and Inactive Men.

International journal of sport nutrition and exercise metabolism·2018
Same author

A Family Based Study of Carbon Monoxide and Nitric Oxide Signalling Genes and Preeclampsia.

Paediatric and perinatal epidemiology·2017
Same author

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

Nature genetics·2017
Same author

High-Intensity Interval Training, Appetite, and Reward Value of Food in the Obese.

Medicine and science in sports and exercise·2017

Related Experiment Video

Updated: Apr 8, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K

Update on genetics of pre-eclampsia.

Linda Morgan1

  • 1University of Nottingham, UK.

Pregnancy Hypertension
|June 25, 2015
PubMed
Summary

Genetic factors significantly contribute to pre-eclampsia risk. Large-scale collaborative studies, including genome-wide association studies (GWAS), are crucial for identifying genetic variants influencing this complex pregnancy condition.

Area of Science:

  • Genetics
  • Obstetrics
  • Genomic Medicine

Background:

  • Familial predisposition to pre-eclampsia is significantly influenced by maternal and/or fetal genetic factors.
  • Genetic research has evolved from candidate gene studies to genome-wide association studies (GWAS).
  • Detecting small-effect genetic variants requires large sample sizes, necessitating collaborative research efforts.

Purpose of the Study:

  • To explore genetic susceptibility variants for pre-eclampsia.
  • To address challenges in replicating genome-wide association study (GWAS) findings.
  • To facilitate meta-analysis of independent GWAS results by emphasizing detailed phenotyping.

Main Methods:

  • Meta-analysis of existing data and genome-wide association studies (GWAS).

More Related Videos

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

16.6K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.2K

Related Experiment Videos

Last Updated: Apr 8, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

16.6K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

9.2K
  • The InterPregGen consortium is conducting GWAS on maternal and fetal genes in 13,000 pregnancies.
  • Future approaches may include deep sequencing and whole genome sequencing for rare variant identification.

    • Main Results:

    • Collaborative meta-analyses suggest a role for thrombophilic polymorphisms in pre-eclampsia.
    • Replication of GWAS findings has been challenging, potentially due to false positives or underpowered replication sets.
    • Pre-eclampsia's complex etiology necessitates large sample sizes for variant detection.

    Conclusions:

    • Collaborative GWAS, like the InterPregGen study, are essential for understanding maternal-fetal gene interactions in pre-eclampsia.
    • Detailed phenotyping is critical for future meta-analyses of GWAS data.
    • Advancements in sequencing technologies promise deeper insights into the genetic basis of pre-eclampsia.