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PP080. First trimester umbilical artery end-diastolic flow and pulsatility index: Comparison between preeclampsia and

Jarmila Zdanowicz, Priska Tappeser, Michael Lengsfeld

    Pregnancy Hypertension
    |June 25, 2015
    PubMed

    Insights

    First-trimester umbilical artery pulsatility index (PI) is higher in women who develop preeclampsia (PE). Early screening using umbilical artery Doppler may help identify PE risk.

    Area of Science:

    • Perinatal medicine
    • Fetal medicine
    • Obstetrics

    Background:

    • End-diastolic flow velocities (EDF) in the umbilical artery (UA) typically appear between 10-14 weeks gestation.
    • UA EDF is linked to spiral artery opening and intervillous space development.

    Purpose of the Study:

    • To compare first-trimester umbilical artery (UA) pulsatility index (PI) and EDF between women who developed preeclampsia (PE) and controls.

    Main Methods:

    • Retrospective search of UA Doppler data between 10-14 weeks gestation.
    • Comparison of UA PI and EDF between severe PE cases and gestational age-matched controls.

    Main Results:

    • 15 severe PE cases were matched with 30 controls.
    • Gestational age with negative EDF was lower in PE cases (12.1 weeks) vs. controls (12.8 weeks).
    • First-trimester UA PI was significantly higher in PE cases (2.45) vs. controls (1.94) when EDF was absent (p=0.038).

    Conclusions:

    • First-trimester UA PI is significantly elevated in women who will develop PE.
    • The timing of UA Doppler screening is crucial for preeclampsia detection.
    Abstract

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