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Random urine albumin:creatinine ratio in high-risk pregnancy - Is it clinically useful?

Dane A De Silva1, Anne C Halstead2, Anne-Marie Côté3

  • 1Department of Pathology and Laboratory Medicine, Children and Women's Health Centre of British Columbia and the University of British Columbia, Vancouver, Canada; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.

Pregnancy Hypertension
|June 25, 2015
PubMed

We evaluated the frequency of measurable albuminuria (⩾6.00mg/L) for albumin:creatinine ratios (ACr) among 160 consecutive women attending high-risk clinics. Of last urine samples before delivery, 76 had measurable albuminuria and 41/76 (53.9%) had ACr ⩾2mg/mmol of which 7.3% had normal pregnancy outcome. 84 samples had albuminuria <6.00mg/L and 43/84 (51.2%) had ACr ⩾2mg/mmol of which 25.6% had normal pregnancy outcome (p=0.025). Excluding 48/160 (30.0%) dilute samples (urinary creatinine <3mM), no samples with unmeasurable albuminuria had ACr ⩾2mg/mmol. In pregnancy, urine is often dilute and without measurable albuminuria, leading to a clinically relevant proportion of false positive results by ACr.

Keywords:
Albumin:creatinine ratioHypertensionMicroalbuminuriaPre-eclampsiaPregnancyProteinuria

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