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Association between low serum magnesium concentration and hyperuricemia.
Chao Zeng1, Yi-lun Wang1, Jie Wei2
1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
Magnesium Research
|June 25, 2015
Summary
Higher serum magnesium levels are linked to a lower prevalence of hyperuricemia (HU) in men. This study found an inverse relationship between magnesium and HU, particularly in the male population.
Area of Science:
- Biochemistry
- Clinical Medicine
- Epidemiology
Background:
- Hyperuricemia (HU) is a condition associated with gout and kidney disease.
- Serum magnesium (Mg) plays a role in various metabolic processes.
- Understanding the relationship between Mg and HU is crucial for public health.
Purpose of the Study:
- To investigate the cross-sectional association between serum magnesium levels and hyperuricemia.
- To determine if this association differs between sexes.
Main Methods:
- A study involving 2904 participants.
- Hyperuricemia defined by specific uric acid thresholds for males and females.
- Multivariable logistic regression analysis adjusted for confounding factors.
Main Results:
- Serum magnesium showed a significant inverse association with hyperuricemia prevalence.
- Higher serum Mg quintiles were associated with decreased odds of HU (P for trend = 0.002).
- In males, increased serum Mg was linked to significantly lower HU odds across higher quintiles (P for trend = 0.003), but no significant association was found in females.
Conclusions:
- Serum magnesium is inversely associated with hyperuricemia.
- This association is significant in the male subgroup.
- No significant association between serum magnesium and hyperuricemia was observed in females.
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