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Analysis of Lipoprotein Subfractions in Chinese Han Patients with Stable Coronary Artery Disease

Rui-Xia Xu1, Yan Zhang1, Ping Ye2

  • 1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Heart, Lung & Circulation
|June 25, 2015
PubMed

Insights

This study found that specific lipoprotein subfractions, including small high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particle size, are linked to coronary artery disease (CAD) in Chinese Han individuals.

Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Population Health

Background:

  • The association between lipoprotein subfractions and stable coronary artery disease (CAD) remains underexplored in the Chinese Han population.
  • Understanding these relationships is crucial for cardiovascular risk assessment in diverse ethnic groups.

Purpose of the Study:

  • To investigate the association between lipoprotein subfractions and stable CAD in a Chinese Han population.
  • To identify specific lipoprotein profiles indicative of CAD presence.

Main Methods:

  • A cohort of 413 patients without lipid-lowering drug treatment was analyzed.
  • Patients were categorized into CAD (n=293) and non-CAD (n=120) groups based on angiographic results.
  • High-density lipoprotein (HDL) and low-density lipoprotein (LDL) subfractions were quantified using the Quantimetrix Lipoprint system.

Main Results:

  • The CAD group exhibited lower levels of large HDL-cholesterol (HDL-C) and reduced mean LDL particle size, alongside higher levels of small HDL-C and increased small HDL subfraction percentage.
  • Intermediate and small LDL-cholesterol (LDL-C) levels and LDL subfraction percentages were also elevated in the CAD group.
  • Logistic regression analysis revealed that small HDL-C level, HDL subfraction percentage, and mean LDL particle size were independently associated with CAD presence.

Conclusions:

  • Lipoprotein subfractions are significantly associated with stable CAD in the Chinese Han population.
  • Findings indicate a higher prevalence of small HDL subfractions and smaller mean LDL particle size in Chinese patients with stable CAD.
  • These results align with Western population studies, suggesting a conserved role of lipoprotein subfractions in CAD pathogenesis across different ethnicities.
Abstract

Keywords:
ChineseCoronary angiographyCoronary artery diseaseHigh-density lipoprotein subfractionLow-density lipoprotein subfraction

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