Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

1.8K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.8K
Modeling in Therapy01:26

Modeling in Therapy

736
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
736
Operant Conditioning Intervention01:24

Operant Conditioning Intervention

663
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
663
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

1.2K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.2K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.6K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.6K
Masking and Demasking Agents01:19

Masking and Demasking Agents

4.0K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus definition for developmental regression during childhood.

Developmental medicine and child neurology·2026
Same author

Study protocol for a pragmatic parallel-group randomised controlled trial to evaluate the effectiveness of coaching with an online intervention, compared with the online intervention alone, for families of children who have experienced developmental regression.

BMJ open·2026
Same author

From waitlists to clinical action: pathway development and research priorities in childhood developmental regression.

The Lancet. Child & adolescent health·2026
Same author

A retrieval-augmented framework enabling VLM spatial awareness for object-centric robot manipulation.

Science robotics·2026
Same author

Follow-up of children born very preterm: the need for evidence-based frameworks to drive best practice and standardised care.

Archives of disease in childhood. Fetal and neonatal edition·2026
Same author

Perinatal palliative care - how to approach antenatal counselling.

Archives of disease in childhood. Education and practice edition·2026

Related Experiment Video

Updated: Apr 8, 2026

Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy
07:21

Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy

Published on: June 27, 2025

603

Chelation for autism spectrum disorder (ASD).

Stephen James1, Shawn W Stevenson, Natalie Silove

  • 1Department of Research, Southwest AutismResearch and Resource Center, Phoenix, AZ,USA.

The Cochrane Database of Systematic Reviews
|June 25, 2015
PubMed
Summary

Chelation therapy using pharmaceutical agents showed no benefit for autism spectrum disorder (ASD) symptoms in a single study. Risks associated with chelation outweigh unproven benefits for ASD.

More Related Videos

A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

12.2K
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.9K

Related Experiment Videos

Last Updated: Apr 8, 2026

Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy
07:21

Electroencephalographic Signal Acquisition Framework for Neurodiverse: A Case Study of Dolphin-Assisted Therapy

Published on: June 27, 2025

603
A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

12.2K
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.9K

Area of Science:

  • Neurodevelopmental Disorders
  • Toxicology
  • Pharmacology

Background:

  • Autism Spectrum Disorder (ASD) symptom severity may correlate with toxic metal levels.
  • Pharmaceutical chelating agents aim to improve ASD symptoms by promoting heavy metal excretion.

Purpose of the Study:

  • To evaluate the efficacy and safety of pharmaceutical chelating agents (chelation therapy) for managing ASD symptoms.

Main Methods:

  • A systematic search identified randomized controlled trials comparing chelation therapy to placebo in individuals with ASD.
  • One study, involving two phases with dimercaptosuccinic acid (DMSA), was included due to limited eligible trials.

Main Results:

  • The included study found no evidence that multiple rounds of oral DMSA effectively improved ASD symptoms in children who were high excreters of heavy metals.
  • Methodological limitations were present in the single included study.

Conclusions:

  • Current clinical trial evidence does not support pharmaceutical chelation as an effective intervention for ASD.
  • Serious adverse events reported with chelation therapy suggest risks outweigh unproven benefits for ASD.
  • Further research requires evidence of a causal link between heavy metals and autism, and improved participant safety protocols.