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Lentiviral-mediated Knockdown During Ex Vivo Erythropoiesis of Human Hematopoietic Stem Cells
Published on: July 16, 2011
In vivo treatment with erythroid differentiation factor (EDF/activin A) increases erythroid precursors (CFU-E and
M Shiozaki1, R Sakai, M Tabuchi
1Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
Biochemical and Biophysical Research Communications
|December 29, 1989
Abstract:
The in vivo effect of human EDF on erythroid precursors (CFU-E and BFU-E) was investigated in normal and bled mice. In anemic (bled) mice, EDF treatment led to significant dose-dependent rises in the CFU-E and BFU-E levels of bone marrow. An elevation in the level of CFU-E was also seen in the spleen. In normal mice, a significant elevation in the level of bone marrow BFU-E was observed. Thus, EDF has an effect on erythropoiesis in anemic and normal mice in vivo.
