Vibration stress and pharmacokinetics of rifampicin

The influence of horizontal vibration stress on pharmacokinetics of rifampicin (RFP) 20 mg.kg-1 on rabbits was investigated. RFP was given orally or intravenously. The experiments were repeated one week later. The drug was administered immediately after 60 min of vibration like in control experiments on the same animals. Another group of animals was exposed to daily vibration for two weeks. The arrangement otherwise was the same as above. Serum levels of orally administered RFP were significantly decreased after a single vibration session. Repeated vibration exposure abolished the observed differences. The single vibration session had no effect on the pharmacokinetics of intravenously applied RFP.