Valence and agency influence striatal response to feedback in patients with major depressive disorder
Jakub Späti1, Justin Chumbley1, Nadja Doerig1
1From the Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan (Späti); the Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Switzerland (Chumbley); the Institute of Psychology, University of Zurich, Zurich, Switzerland (Doerig, Grosse Holtforth); the Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland (Brakowski, Seifritz); the Department of Psychology, University of Bern, Bern, Switzerland (Grosse Holtforth); the Preclinical Laboratory for Translational Research into Affective Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland (Spinelli); the Neuroscience Center, University and ETH Zurich, Zurich, Switzerland ( Spinelli); and the Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland ( Seifritz, Spinelli).
Background:
Reduced sensitivity to positive feedback is common in patients with major depressive disorder (MDD). However, findings regarding negative feedback are ambiguous, with both exaggerated and blunted responses being reported. The ventral striatum (VS) plays a major role in processing valenced feedback, and previous imaging studies have shown that the locus of controls (self agency v. external agency) over the outcome influences VS response to feedback. We investigated whether attributing the outcome to one's own action or to an external agent influences feedback processing in patients with MDD. We hypothesized that depressed participants would be less sensitive to the feedback attribution reflected by an altered VS response to self-attributed gains and losses.
Methods:
Using functional MRI and a motion prediction task, we investigated the neural responses to self-attributed (SA) and externally attributed (EA) monetary gains and losses in unmedicated patients with MDD and healthy controls.
Results:
We included 21 patients and 25 controls in our study. Consistent with our prediction, healthy controls showed a VS response influenced by feedback valence and attribution, whereas in depressed patients striatal activity was modulated by valence but was insensitive to attribution. This attribution insensitivity led to an altered ventral putamen response for SA - EA losses in patients with MDD compared with healthy controls.
Limitations:
Depressed patients with comorbid anxiety disorder were included.
Conclusion:
These results suggest an altered assignment of motivational salience to SA losses in patients with MDD. Altered striatal response to SA negative events may reinforce the belief of not being in control of negative outcomes contributing to a cycle of learned helplessness.
Related Concept Videos
01:27Depressive Disorders: MDD and Dysthymia
01:27Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
01:30Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
01:23Antidepressant Drugs: MAOIs and Other Agents