Kinetics of a heterogeneous population of particles in low density lipoprotein apolipoprotein B

This paper examines the kinetics of low density lipoprotein (LDL) metabolism following the in vivo injection of native and chemically-modified lipoproteins in an attempt to assess the relative importance of receptor-dependent and receptor-independent catabolic pathways. The shape of the urinary/plasma ratio curve suggested heterogeneity of the LDL-apolipoprotein B pool and excluded homogeneity. This heterogeneity required the building of a more complex model that allowed the simultaneous fitting of plasma and urinary data. This new model permits the precise quantification of both receptor and non-receptor pathways.