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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
Published on: September 24, 2021
Acute pericarditis
Márcio Tonini1, Dirceu Thiago Pessoa de Melo2, Fábio Fernandes2
1Heart Institute, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Abstract:
Acute pericarditis is a common disease caused by inflammation of the pericardium, usually benign and self-limited and can occur as an isolated or as a manifestation of a systemic disease entity. Represents 5% of all causes of chest pain in the emergency room. The main etiology are viral infections, although it can also be secondary to systemic diseases and infections. The main complication of acute pericarditis is pericardial effusion, triggering a cardiac tamponade. The first line of treatment is the use of anti-inflammatory and or acetylsalicylic acid. Most patients have a good initial response to an NSAID associated to colchicine and became asymptomatic within a few days. This review article seeks to contemplate the main clinical findings and armed investigation to optimize the diagnosis of this important disease, as well as addressing their therapeutic management.
Insights
Acute pericarditis, an inflammation of the pericardium, is often caused by viruses. Effective treatment involves anti-inflammatory drugs and colchicine, leading to rapid symptom relief for most patients.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Acute pericarditis is a common condition involving pericardial inflammation, frequently benign and self-limiting.
- It accounts for 5% of emergency room chest pain cases, often stemming from viral infections or systemic diseases.
- A key complication is pericardial effusion, potentially leading to cardiac tamponade.
Purpose of the Study:
- To review the primary clinical findings and diagnostic investigations for acute pericarditis.
- To outline the optimal therapeutic management strategies for this condition.
Main Methods:
- This is a review article synthesizing current knowledge on acute pericarditis.
- It focuses on clinical presentation, diagnostic approaches, and treatment protocols.
Main Results:
- Viral infections are the most frequent cause of acute pericarditis.
- Initial treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) combined with colchicine yields good patient response and rapid symptom resolution.
- Early diagnosis and appropriate management are crucial for preventing complications like cardiac tamponade.
Conclusions:
- Acute pericarditis requires prompt diagnosis and management to prevent severe complications.
- A combination of NSAIDs and colchicine is a highly effective first-line therapy.
- This review provides a comprehensive overview for optimizing patient care.
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