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Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
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Retinal Vein Occlusions.

Jost B Jonas1, Dennis S C Lam

  • 1From the *Department of Ophthalmology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; and †State Key Laboratory (Ophthalmology) and Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Asia-Pacific Journal of Ophthalmology (Philadelphia, Pa.)
|June 25, 2015
PubMed
Summary
This summary is machine-generated.

Retinal vein occlusions (RVOs) are a common vascular disorder. Current treatments like intravitreal injections reduce swelling and improve vision, but recurrence prevention remains unproven.

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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Retinal Diseases

Background:

  • Retinal vein occlusions (RVOs) are a significant cause of vision loss, second only to diabetic retinopathy.
  • Characterized by retinal vein dilation, hemorrhages, macular edema, and potential atrophy.
  • Classified into central, branch, ischemic, and non-ischemic types, with further sub-classification for BRVOs.

Purpose of the Study:

  • To review the diagnosis, risk factors, and treatment modalities for retinal vein occlusions.
  • To compare historical and current therapeutic approaches for RVOs.
  • To highlight the prognostic value of spectral-domain optical coherence tomography (SD-OCT).

Main Methods:

  • Diagnosis relies on ophthalmoscopy, fluorescein angiography, and SD-OCT.
  • SD-OCT provides crucial information on retinal structure for prognosis and treatment guidance.
  • Review of existing literature on RVO risk factors, pathogenesis, and treatment outcomes.

Main Results:

  • Risk factors include glaucoma and arterial hypertension; ischemic RVOs can lead to neovascularization and glaucoma.
  • Traditional laser photocoagulation caused retinal damage.
  • Intravitreal therapies (steroids, anti-VEGF) effectively reduce macular edema and improve vision temporarily without retinal damage.

Conclusions:

  • Intravitreal therapies offer a safer alternative to laser for RVOs, improving visual function.
  • SD-OCT is vital for assessing retinal integrity and guiding RVO management.
  • Preventive strategies against RVO recurrence or contralateral eye involvement are still under investigation.