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Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
10:47

Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice

Published on: April 14, 2011

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Influenza infection and Kawasaki disease

Xijing Huang1, Ping Huang1, Li Zhang1

  • 1Heart Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.

Revista Da Sociedade Brasileira De Medicina Tropical
|June 25, 2015
PubMed

Insights

Influenza infection may worsen Kawasaki disease (KD) symptoms, leading to higher rates of incomplete KD and longer fevers. Further research is needed to determine if flu causes KD.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Rheumatology

Background:

  • Kawasaki disease (KD) is a critical pediatric illness.
  • The potential association between influenza (Flu) infection and KD requires investigation.

Purpose of the Study:

  • To explore the link between concurrent influenza infection and Kawasaki disease.
  • To compare clinical characteristics and outcomes of KD patients with and without influenza.

Main Methods:

  • Retrospective analysis of 1,053 KD cases and 4,669 influenza cases (2011-2013).
  • Matched cohort design comparing KD + Flu group with KD and Flu-only groups.
  • Evaluated clinical manifestations, disease course, incomplete KD, IVIG resistance, and echocardiographic findings.

Main Results:

  • The KD + Flu group showed a higher incidence of incomplete KD.
  • Patients with concurrent influenza experienced longer delays in KD diagnosis and prolonged fever duration.
  • Elevated CRP and ESR levels were observed in the KD + Flu group compared to controls.

Conclusions:

  • Concurrent influenza infection significantly alters KD clinical presentation and diagnostic markers.
  • Influenza impacts KD diagnosis, treatment, and laboratory findings.
  • The etiological role of influenza in Kawasaki disease remains undetermined.
Abstract

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