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B7-H3 expression in children with asthma exacerbation
Zhengrong Chen1, Guangbo Zhang, Yuqing Wang
1Department of Respiratory Disease, Soochow University Affiliated Children's Hospital, Soochow University, Suzhou, China.
Allergy and Asthma Proceedings
|June 25, 2015
Summary
Elevated B7-H3 levels are found in children with asthma exacerbation, suggesting its role in the condition. B7-H3 may serve as a valuable biomarker for assessing asthma exacerbations in pediatric patients.
Area of Science:
- Immunology
- Pediatric Pulmonology
- Biomarker Discovery
Background:
- B7-H3, a member of the B7 family, is implicated in asthma development.
- Understanding B7-H3's role in pediatric asthma exacerbations is crucial.
Purpose of the Study:
- To investigate the expression levels of B7-H3 in children experiencing asthma exacerbation.
- To correlate B7-H3 levels with clinical parameters and cytokine profiles in pediatric asthma.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure B7-H3 and cytokine levels (IFN-γ, IL-4, IL-10).
- Clinical data, including FEV(1) and fractional exhaled nitric oxide, were collected from 21 children with asthma exacerbation and 18 controls.
- B7-H3 levels were compared between asthmatic children and controls, and in relation to treatments like inhaled corticosteroids and prednisone.
Main Results:
- Children with asthma exacerbation exhibited significantly higher B7-H3 levels compared to controls.
- Asthma exacerbation was associated with elevated IL-4 and reduced IFN-γ levels.
- B7-H3 levels were lower in patients receiving inhaled corticosteroids and decreased after prednisone treatment, showing an inverse correlation with IFN-γ.
Conclusions:
- B7-H3 plays a significant role in pediatric asthma exacerbation.
- B7-H3 demonstrates potential as a clinical biomarker for evaluating the severity of asthma exacerbations in children.
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