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Association of urine CC16 and lung function and asthma in Chinese children

Ya-Nan Ma1, Jing Wang, Yungling Leo Lee

  • 1Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, Liaoning Province, PR China.

Allergy and Asthma Proceedings
|June 25, 2015
PubMed

Insights

Urinary Club cell secretory protein-16 (CC16) levels were lower in Chinese children with asthma. Lower urine CC16 also correlated with reduced lung function, suggesting its potential as a biomarker for pediatric respiratory health.

Area of Science:

  • Pediatric Pulmonology
  • Biomarkers
  • Respiratory Health

Background:

  • Serum Club cell secretory protein-16 (CC16) is linked to respiratory diseases.
  • Limited research exists on urinary CC16 in relation to respiratory conditions.

Purpose of the Study:

  • To investigate the association between urinary CC16 and physician-diagnosed asthma in Chinese children.
  • To examine the relationship between urinary CC16 and lung function measurements in this population.

Main Methods:

  • Cross-sectional study of 147 children with asthma and 390 healthy children (ages 9-15) in China.
  • Measurement of lung function (FEV1, FVC) using spirometers.
  • Quantification of urinary CC16 via enzyme-linked immunoassay and assessment using multiple regression models.

Main Results:

  • Lower creatinine-adjusted urinary CC16 levels were observed in children with asthma.
  • Urinary CC16 showed a significant association with asthma diagnosis (OR 0.782).
  • A positive correlation was found between urinary CC16 and forced vital capacity (beta 0.064).

Conclusions:

  • Asthmatic children exhibited lower urinary CC16 levels and reduced lung function.
  • Urinary CC16 may serve as a valuable biomarker for assessing lung epithelium integrity in pediatric asthma and lung injury.
Abstract

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