Related Experiment Video

Updated: Apr 8, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.9K

Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary

Chenggui Liu1, Yinzhong Yang, Duanliang Peng

  • 1Department of Clinical Laboratory, Chengdu Women's and Children's Central Hospital, Chongqing Medical University, Chengdu, China. E-mail. lablcg@126.com.

Saudi Medical Journal
|June 26, 2015
PubMed

Insights

High homocysteine levels (HHcy) are strongly linked to severe coronary heart disease (CHD). Low folic acid and vitamin B12 status are common in CHD patients with HHcy, indicating a significant correlation.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Nutritional Science

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Hyperhomocysteinemia (HHcy), elevated levels of homocysteine, is a potential risk factor for cardiovascular diseases.
  • Understanding the association between HHcy and CHD severity is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the relationship between hyperhomocysteinemia (HHcy) and the severity of coronary heart disease (CHD).
  • To determine the prevalence of HHcy across different categories of CHD.
  • To explore the correlation between HHcy and key vitamin deficiencies (folic acid, vitamin B12).

Main Methods:

  • Retrospective analysis of metabolic parameters, anthropometrics, and lifestyle in 292 CHD patients and 100 non-CHD controls.
  • Categorization of CHD patients into stable angina pectoris (SAP), unstable angina pectoris, and acute myocardial infarction (AMI).
  • Multivariate logistic regression and correlation analyses to assess associations and relationships.

Main Results:

  • Prevalence of HHcy was significantly higher in CHD patients (79.1%) compared to non-CHD controls (5%).
  • HHcy prevalence increased progressively with CHD severity: SAP (66%), unstable angina (81.9%), and AMI (93.15%).
  • HHcy was independently associated with CHD severity (AMI vs. SAP, OR=6.38) and negatively correlated with folic acid and vitamin B12 levels.

Conclusions:

  • Hyperhomocysteinemia is an independent risk factor associated with increased severity of coronary heart disease.
  • Low levels of folic acid and vitamin B12 are significantly correlated with HHcy in CHD patients.
  • These findings highlight the importance of monitoring homocysteine and vitamin status in CHD management.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
773
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.7K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
748
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
861
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
998
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
700