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Related Concept Videos

Quality Control01:05

Quality Control

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Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
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Coagulation01:06

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Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
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Coagulation01:09

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
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Quality Assurance01:19

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Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
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Related Experiment Video

Updated: Apr 8, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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Internal Quality Control Practices in Coagulation Laboratories: recommendations based on a patterns-of-practice

A McFarlane1, B Aslan1, A Raby1

  • 1Institute for Quality Management in Healthcare (IQMH), Toronto, ON, Canada.

International Journal of Laboratory Hematology
|June 26, 2015
PubMed
Summary
This summary is machine-generated.

Internal quality control (IQC) practices for coagulation testing show variability among Ontario laboratories. Standardized IQC procedures are recommended to improve accuracy and reliability of patient test results.

Keywords:
Coagulationhemostasislaboratory practicequality control

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Area of Science:

  • Clinical Laboratory Science
  • Hematology
  • Quality Assurance

Background:

  • Internal quality control (IQC) is essential for accurate patient test results.
  • The IQMH Centre for Proficiency Testing surveyed current IQC practices in coagulation testing.

Purpose of the Study:

  • To investigate current internal quality control (IQC) practices in coagulation testing.
  • To identify variability in IQC procedures among Ontario laboratories.

Main Methods:

  • A web-based survey was conducted.
  • 174 Ontario laboratories performing prothrombin time (PT) and activated partial thromboplastin time (APTT) were surveyed.

Main Results:

  • All labs use commercial QC (CQC); 12% use pooled patient plasma.
  • >68% run CQC at shift start, 56% post-maintenance/reagent changes.
  • IQC frequency often follows manufacturer recommendations (71%), with variability in monitoring (SD, precision goals) and failure actions.

Conclusions:

  • Significant variability exists in coagulation IQC practices across Ontario laboratories.
  • Standardized IQC practices are recommended to enhance accuracy and reliability.