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Related Concept Videos

Human Genetics01:28

Human Genetics

1.9K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Genetic Lingo01:11

Genetic Lingo

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Overview
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Incomplete Dominance01:43

Incomplete Dominance

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
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Elecsys Cerebrospinal Fluid Assays Accurately Distinguish Alzheimer's Disease from Frontotemporal Lobar Degeneration.

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Related Experiment Video

Updated: Apr 8, 2026

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

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[Genetics of dementia].

J Diehl-Schmid1, K Oexle

  • 1Klinik und Poliklinik für Psychiatrie und Psychotherapie, TU München, Ismaninger Str. 22, 81675, München, Deutschland, janine.schmid@lrz.tum.de.

Der Nervenarzt
|June 26, 2015
PubMed
Summary

Rare familial Alzheimer's disease and frontotemporal lobar degeneration follow autosomal dominant inheritance. Genetic counseling is recommended for suspected Mendelian inheritance patterns in dementia cases, adhering to German genetic laws.

Area of Science:

  • Neurology
  • Genetics
  • Psychiatry

Context:

  • Most adult psychiatric diseases, including dementia, are multifactorial.
  • Rare familial forms of Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) exhibit autosomal dominant (Mendelian) inheritance.
  • AD caused by mutations in PSEN1, PSEN2, or APP genes typically manifests before age 65.

Purpose:

  • To highlight the genetic basis of rare familial dementia subtypes.
  • To emphasize the importance of genetic counseling in suspected autosomal dominant dementia cases.
  • To align with current German clinical guidelines for dementia management.

Summary:

  • Familial Alzheimer's disease and frontotemporal lobar degeneration can follow an autosomal dominant inheritance pattern.

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Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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  • Mutations in APP, PSEN1, and PSEN2 genes are associated with early-onset familial Alzheimer's disease.
  • Approximately 10% of frontotemporal lobar degeneration cases are dominantly inherited.

    • Impact:

    • Informs clinical practice regarding genetic counseling for dementia.
    • Supports adherence to the German Genetic Diagnostics Act (Gendiagnostikgesetz).
    • Underscores the role of genetic factors in specific dementia etiologies.