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Differences in survival outcome between stage I and stage II glottic cancer: A SEER-based analysis
Jonathan J Chen1, Alexander Stessin2, Paul Christos3
1Weill Cornell/Sloan-Kettering/Rockefeller Tri-Institutional MD-PhD Program, New York, New York, U.S.A.
Objective:
The purpose of this study was to investigate and compare the cause-specific survival (CSS) of stage I (tumor [T]1 node [N]0 metastasis [M]0) versus stage II (T2N0M0) glottic cancer in a large population cohort.
Study Design:
We analyzed data from the Surveillance, Epidemiology, and End Results 18 database from 1973 to 2009, comprising patients diagnosed with T1N0M0 or T2N0M0 squamous cell glottic cancer. Kaplan-Meier survival analysis, multivariable Cox proportional hazards regression analysis, and competing-risks survival regression were used for statistical analysis.
Results:
There were 4,422 patients who met all inclusion criteria. The 36-month CSS was 93.9% for stage I verus 86.5% for stage II, with P < 0.0001. Stage II status conferred a 2.494 hazard ratio for increased risk of cause-specific death compared to stage I.
Conclusions:
Stage II glottic cancers have a significantly worse prognosis and may need a different approach to management than stage I tumors.
Level Of Evidence:
4.